Full list of all 46 Slay the Spire achievements. It takes around 60-80 hours to unlock all of the achievements in the base game on Windows.
The base game contains 26 achievements, and there are 8 DLC packs containing 20 achievements.
Obtain all other Achievements.
Beat the game with a single relic.
Beat the game in under 20 minutes.
Beat the game with a 5 card deck or smaller.
Finish Donu with a Feed.
Unlock Ascension mode.
Complete Ascension Level 10.
Beat the game with the Defect.
Beat the game with a deck containing no uncommons or rares.
Have 25 or more Focus during combat.
Channel 9 Plasma in a single turn.
Win a Daily Climb.
Defeat the Transient before it fades away.
Complete Ascension Level 20.
Complete the Ending with the Ironclad.
Complete the Ending with the Silent.
Complete the Ending with the Defect.
Complete the Ending with the Ironclad, Silent, and Defect.
Beat the game with the Watcher.
Complete the Ending with the Watcher.